Why does ldl get oxidized

Macrophages engulf oxidized LDLs, forming new fat-filled cells, which aggregate, stick to blood vessel walls and become plaque. Oxidized LDLs significantly contribute to the development of atherosclerosis, according to the Medical Biochemistry Page. They also inhibit the production of nitric oxide, which helps prevent atherosclerosis by relaxing blood vessels. High-density lipoproteins, or HDLs, consist of more proteins than cholesterol. In addition to this reverse cholesterol transport system, enzymes in HDLs have an antioxidant effect, which may prevent LDLs from being oxidized.

HDLs also help prevent cardiovascular disease by relaxing blood vessels and having an anti-inflammatory effect, according to the Medical Biochemistry Page. Higher levels of HDLs circulating in your bloodstream are associated with a lower risk for heart disease. You may lower LDLs 8 to 10 percent by limiting saturated fats to less than 7 percent of your total daily calories, which is 15 grams on a 2,calorie diet. But the cardinal rule of Omegas 3 and 6 is small quantities. Eat a Mickey Ds french fry?

Your need for counter-balancing Omega-3s just went up. And we need to stop and think about the effects of eating incredibly artificial amounts of Omega OxLDL is involved in the early stages of heart disease and artery damage. Certainly better than total cholesterol. LDL is a toss up — with it, you can predict heart disease half the time. Another reason to cut down on sugar and refined carbs.

Doctors are still quick to prescribe statin drugs for lowering cholesterol, without much discussion about the risk of excess vegetable oils or oxLDL. In some people, this added risk from statins is worth it. Is it for you? Ask your doctor. For me, no. This product is not intended to diagnose, treat, cure, or prevent any disease. Vin, I can bet my endocrinologist and my GP are going to be pushing me even harder to get on the statin bandwagon, since I have diabetes and RA.

Yet I had a LipoScience test done on me that indicated I had very few small dense particles probably thanks to my Paleo diet and fish oil and avoidance of seed oils and wheat.

Well, you pay doctors to give you their best advice. Usually, they are right. But he is very interested in my triglycerides and HDL, neither of which are affected much by statins. You have enviable HDL and triglyceride numbers — both are more telling of heart risk than LDL and far more telling than total chol.

Your A1C is just on the scary side of normal. I am not sure that there is any evidence to suggest that fish oil derived omega 3 has any protective effect on the oxidation of LDL.

This is not surprising. Well, honored to have you here, Sampath. Would love to hear your thoughts on preventing LDL oxidation. Hi Gloria — yes, many labs now offer it. What about alge based Omega 3? Hi Michael — algae based Omega-3 are fine if you are a vegan. Otherwise, it is expensive and not very concentrated. This article should be re-published. Some of these comments here appall me.

Doctors in all factual honesty do not know this information. They still prescribe statins at an alarming rate because they are paid by the pharmaceutical to do so and they still tell people to avoid all saturated fats.

Most doctors are out of touch and incompetent. We have to use the internet to seek out our own information and find the truth. Hi Jay — while I agree with you that some of the information above needs a wider audience, including doctors. A small number of educated, informed, and scientifically well-versed individuals will be able to guide themselves with self-care.

However, the vast majority of people are not able to distinguish good information from nonsense that chokes the internet. I urge readers to take this information to their doctors and make a wise choice together.

Many doctors will get offended if you take an article from the internet and tell them to follow a different protocol. That should not be surprising. I am concerned about directing people away from doctors because most doctors are not incompetent. I go to 2 or 3 doctors who know all this and then some. The trick is to find the right doctor. So, this is My fourth blood test in a year showing high oxidized LDL. Plus my omega are low.

They are 3. My cholesterol and triglycerides are fine. I try to eat vegan, lots of nuts, and lots of vegetables. I am 58 and a little freaked out. I just had some avocado and more fish oil tabs! What else can I take to reduce my high oxidized LDL? Any help would be appreciated, thank you!

Hi Karen — the prevention of LDL oxidation is somewhat of a rabbit hole…but I will try my best to simplify it for you. Over time, more macrophages, cholesterol, and other lipids begin to accumulate at the site which is usually sticky causing the plaques to grow. Plaque buildup can partially or completely restrict blood flow within an artery, which increases a person's risk for coronary heart disease, peripheral vascular and cerebrovascular disease.

While research has largely indicated that oxidized LDL cholesterol has a negative affect on the body, some preliminary studies have brought interesting new theories into the discussion, such as the potential for oxidized LDL to be protective.

You may be able to reduce and prevent oxidized LDL by:. High LDL cholesterol levels can place you at risk for developing cardiovascular disease, and the type of LDL circulating in your blood matters. Oxidized LDL is increasingly recognized as a contributor to heart disease, vascular disease, and stroke.

It is generally not considered helpful to do a specialized test to measure oxidized LDL. Levels of oxidized LDL generally correlate with the presence of other, easily detected risk factors, such as those listed above. Actually measuring oxidized LDL, therefore, usually doesn't add much to your healthcare provider's ability to estimate your overall cardiovascular risk.

Looking to start a diet to better manage your cholesterol? Changing lifelong eating habits can be scary at first, but our guide will make it easier. Canadian Journal of Cardiology. McGraw-Hill Education; ; Oxidized low density lipoproteins: The bridge between atherosclerosis and autoimmunity. Possible implications in accelerated atherosclerosis and for immune intervention in autoimmune rheumatic disorders. Autoimmunity Reviews.

Cholesterol, inflammation and innate immunity. Nat Rev Immunol. Oxidized LDL-activated platelets induce vascular inflammation. Semin Thromb Hemost. Antioxidative activity of high-density lipoprotein HDL : Mechanistic insights into potential clinical benefit. BBA Clinical. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases.

Critical Reviews in Clinical Laboratory Sciences. Meyer, A. Ji, L. Cai, D. Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation.